Recherche

RESEARCH LABORATORY

in Biotechnology & Bioinformatics

Biotech & Bioinfo Laboratory
LABORATORY ACTIVITIES:

The laboratory activities are mainly focused on the study of antibiotic resistance mechanisms and virulence in Gram negative and positive bacteria

All research projects conducted aim to characte- rize the emergence and diffusion of multiresis- tant clones at the hospital and community level

Les chimistes professionnels s'adaptent à l'analyse du développement de vaccins et pointent sur un écran de pc dans un laboratoire équipé
RESEARCH TOPICS
Monitoring of antimicrobial resistances
  • Evolution of antibiotic resistance
  • Characterization of resistance genes: ESBL, CPE, PMQR, VanR and mec A genes
Detection of virulence genes

Therapeutic alternatives

  • Identification of natural or synthetic molecules having a bactericidal or antibiofilm effects
Identification and detection of biofilms
  • Biofilm formation ability and quantification
  • Effect of disinfectants on the adhesion and biofilms formation
BIOINFORMATICS ANALYSIS AND COMPUTER-AIDED DRUG DISCOVERY
Évaluation des performances des protocoles de calcul d'amarrage moléculaire et d'énergie libre

Understanding resistance mechanisms through molecular modeling and structural analysis

Synthèse et évaluation biologique d’analogues de la ranitidine

Active site prediction.

Pose de liaison et site de liaison de l'acide caféique avec l'α-glucosidase (panneau A)

Virtual screening based on structure to discover new highly potent antibacterial agents.

Molecular dynamic simulation free binding energy calculation

Molecular dynamics simulation and calculation of free binding energy.